AHEART June 47/6

نویسندگان

  • RÉMI NEVIÈRE
  • BENOIT GUERY
  • SERGE MORDON
  • FARID ZERIMECH
  • STÉPHANE CHARRÉ
  • FRANCIS WATTEL
  • CLAUDE CHOPIN
  • Benoit Guery
  • Serge Mordon
  • Farid Zerimech
  • Stéphane Charré
  • Francis Wattel
چکیده

Nevière, Rémi, Benoit Guery, Serge Mordon, Farid Zerimech, Stéphane Charré, Francis Wattel, and Claude Chopin. Inhaled NO reduces leukocyte-endothelial cell interactions and myocardial dysfunction in endotoxemic rats. Am J Physiol Heart Circ Physiol 278: H1783–H1790, 2000.— Inhaled nitric oxide (NO) has been shown to have some protective effect in the peripheral distal inflamed vasculature. The objective of the study was to determine whether inhaled NO would reduce endotoxin-induced leukocyte activation and myocardial contractile dysfunction. Rats were treated with either saline or endotoxin (10 mg/kg iv) and then allowed to breathe (4 h) either air or air plus NO (10 ppm). In endotoxemic rats, mesenteric venular endothelium leukocyte firm adhesion increased compared with control rats (1.15 6 0.32 vs. 4.08 6 0.96 leukocytes/100 μm; P , 0.05). Inhaled NO significantly attenuated endotoxin-induced venular endothelium leukocyte adhesion (4.08 6 0.96 vs. 1.86 6 0.76 leukocytes/100 μm; P , 0.05) and FITC-conjugated anti-intercellular adhesion molecule-1 fluorescence intensity. Endotoxininduced myocardial dysfunction and leukocyte content increases were reduced in inhaled NO-treated rats. These observations suggest that inhaled NO reduces the degree of cardiovascular dysfunction and inflammation in endotoxemic rats.

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تاریخ انتشار 2000